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Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region

Author:

Takuya Otsuki,Shigeyuki Matsumoto,Junso Fujita,Tomoko Miyata,Keiichi Namba,Ryo Kanada,Yasushi Okuno,Haruhiko Kamada,Hiroaki Ohno,Hiroki Akiba

Publication:

Journal of Biological Chemistry

Publisher:

Elsevier

Date:

September 2025

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