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The inefficiency of incisions of ecteinascidin 743–DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

Author:

Maha Zewail-Foote,Ven-Shun Li,Harold Kohn,David Bearss,Mary Guzman,Laurence H Hurley

Publication:

Chemistry & Biology

Publisher:

Elsevier

Date:

November 2001

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