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Multiple Mechanisms of Resistance to Polyglutamatable and Lipophilic Antifolates in Mammalian Cells: Role of Increased Folylpolyglutamylation, Expanded Folate Pools, and Intralysosomal Drug Sequestration

Author:

Gerrit Jansen,Haim Barr,Ietje Kathmann,Marlene A. Bunni,David G. Priest,Paul Noordhuis,Godefridus J. Peters,Yehuda G. Assaraf

Publication:

Molecular Pharmacology

Publisher:

Elsevier

Date:

April 1999

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