Morphological changes induced by buffer exchange during preparation of mRNA-lipid nanoparticles occur in a stepwise manner as pH is elevated

Author:

Yujia He,Emily H. Pilkington,Hee Jung Kang,Wye-Khay Fong,Andrew J. Clulow,Angus P.R. Johnston,Colin W. Pouton

Publication:

Molecular Therapy - Methods & Clinical Development

Publisher:

Elsevier

Date:

11 December 2025

Crown Copyright © 2025 Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.

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